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KMID : 0363620070280040124
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Journal of Korean Oriental Medicine
2007 Volume.28 No. 4 p.124 ~ p.135
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Analgesic and Anti-Inflammatory Effect of Scutellaria Baicalensis
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Lee Joong-Keun
Song Yun-Kyung
Lim Hyung-Ho
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Abstract
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Backgrounds : Scutellaria baicalensis has been used as a medicinal plant to treat various disease conditions accompanying inflammatory response and oxidative stress.
Objectives : The aim of this study is to evaluate the effects of Scutellaria baicalensis against inflammatory, pain and edema
Methods : In vitro, the effects of Scutellaria baicalensis against lipopolysaccharide-induced inflammation were investigated in mouse BV2 microglial cells. In vivo, the effects of Scutellaria baicalensis on acetic acid-induced writhing response, carrageenan-induced edema and the plantar test (nociceptive thermal stimulation) were investigated using rats and mice.
Results : The present results showed that pre-treatment with the aqueous extract of Scutellaria baicalensis suppressed the lipopolysaccharide-stimulated cyclooxygenase-2 expressions in mouse BV2 microglial cells. The aqueous extract of Scutellaria baicalensis inhibited acetic acid-induced abdominal pain in mice and also reduced thermal pain in rats. However, no significant inhibition on carrageenan-induced edema in rats.
Conclusions : The present study showed that Scutellaria baicalensis possesses anti-inflammatory and analgesic effects.
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KEYWORD
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Scutellaria baicalensis, analgesic, anti-inflammatory
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